请将以下英文翻译成中文?非常感谢

The role of the intracellular signaling pathways activated by PTH and PTHrP, which regulate the cell cycle in osteoblasts, are yet to be defined. PTH has been shown to inhibit osteoblast proliferation by increasing p27 levels and inhibiting CDK2 activity [223]. Gene array analysis showed differential expressions of cyclins, Bcl-2 family members, as well as p53 during differentiation of a mouse calvarial-derived cell line to acquire an osteoblast like phenotype [224]. PTHrP, on the other hand, has been shown to target cyclin D1, CDK1 p21, p27 and p16 protein in differentiated osteoblasts and induced G1 phase growth arrest [61]. In differentiated osteoblasts, PTHrP reduces CDK1 activity and down-regulates cyclin D1 level possibly via decreased phosphorylation and stabilization of JunB, a member of AP-1 transcription factor [61].

如果有好心人愿意帮助的话,将全文翻译一下,我愿意以酬谢!!!
全文网址:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723940/?tool=pubmed

现在没时间了,我下班以后到家再试试看,回家修改答案,你这个太专业了,我只能翻译大体意思,具体的还是需要你的专业知识。
全文翻译的太难了,你最好找一个生物学的博士。
我勉强帮你翻译这段。
细胞内的信号路径通过PTH和PTHrP激活,从而调节细胞周期中的成骨细胞的作用,还有待确定。PHT已被证明能够通过抑制p27蛋白水平增加来抑制成骨细胞的增值,同时抑制CDK2的活性。基因阵列分析表明,细胞周期蛋白表达差异,Bcl - 2的家族成员,以及p53在从源于老鼠颅骨细胞株变异期间表型成骨细胞。从另一方面讲,PTHrP已被证明以细胞周期蛋白D1,CDK1,p21,p27和p16蛋白质为目标分化为成骨蛋白和诱导G1期生长停滞。在已分化的成骨细胞中, PTHrP可能通过减少AP-1转录因子成员之一的JunB稳定性和磷酸化作用降低CDK1的活性和抑制细胞周期蛋白D1的水平。
太TMD的难了。
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第1个回答  2011-01-10
Please translate the fowlling into Chinese.
第2个回答  2011-01-10
在细胞内的信号通过PTH和肽,从而调节细胞周期中的成骨细胞激活途径的作用,还有待确定。普通话已被证明能够抑制p27蛋白水平增加,抑制CDK2的活性[223]成骨细胞的增殖。基因芯片分析表明,细胞周期蛋白表达差异,Bcl - 2家族成员,以及在有老鼠的颅骨来源的细胞系,收购样表型[224]成骨细胞分化的p53基因。肽,另一方面,已被证明为目标细胞周期蛋白D1,CDK1的p21基因,p27和p16在诱导分化为成骨蛋白和G1期生长停滞[61]。在分化成骨细胞,降低CDK1的活性肽和下通过调节细胞周期蛋白磷酸化和JunB下降,一对AP -1转录因子D1级成员的稳定可能[61]。
第3个回答  2011-01-10
中所扮演的角色,激活细胞内信号途径和PTHrP镀通孔失效,在细胞周期调节成骨细胞,还没有被定义。已经证实,镀通孔失效成骨细胞增殖抑制通过增加与抑制CDK2活动有多远水平[223]。基因阵列分析显示,它的表达Bcl-2差家庭成员,以及在465 calvarial-derived老鼠细胞分化成骨细胞添置一个线[224像表型)。PTHrP,另一方面,已被证实的目标,CDK1 p21 cyclin D1 p16蛋白质,有多远,分化成骨细胞和归纳G1期增长逮捕[上图)。在分化成骨细胞CDK1活动和down-regulates PTHrP减少cyclin D1水平可能通过降低、稳定的蛋白质磷酸化的成员JunB转录因子AP-1[上图)。

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