alt+f11新建一个模块
粘贴下面代码
Private Sub RegExp_Replace()
Dim RegExp As Object
Dim SearchRange As Range, Cell As Range
'此处定义正则表达式
Set RegExp = CreateObject("vbscript.regexp")
RegExp.Pattern = "0*$"
'此处指定查找范围
Set SearchRange = ActiveSheet.Range("A1:A99")
'遍历查找范围内的单元格
For Each Cell In SearchRange
Set Matches = RegExp.Execute(Cell.Value)
If Matches.Count >= 1 Then
Set Match = Matches(0)
Cell.Value = RegExp.Replace(Cell.Value, "")
End If
Next
End Sub
"A1:A99" 换成你实际的 范围 然后点 运行就行了