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Question

本文依据分子钟假说和Dayhoff的氨基酸突变的概率矩阵模型，运用计算机程序来模拟从随机产生的初始蛋白质序列开始的突变进化过程，并收集模拟实验数据，运用统计学方法处理和分析数据。由此，分别得出祖先序列与进化序列之间、随机趋异的两个同源序列之间的一致性与氨基酸突变数关系的模型。同时分析了同源序列间的差异率和可接受突变位点之间的关系，估算出不同位点的突变率在服从 分布的情况下的形状参数 ，对于祖先序列与进化序列之间为2.25，对于随机趋异的两个同源序列之间则为1.9。

Answer 1

In this paper, based on molecular clock hypothesis and the amino acid mutations Dayhoff the probability matrix model, using a computer program to simulate randomly generated from the initial start of the mutant protein sequence of evolutionary process, and data collection simulation experiments, the use of statistical methods of data processing and analysis. Thus, our ancestors were drawn between the sequence of evolutionary sequence, random divergence between the two homologous sequence of amino acid mutations and the consistency of the model. At the same time homologous sequence of the difference between an acceptable rate of mutation, and the relationship between the different sites to estimate the mutation rate in the case of distribution subject to the shape parameters, the ancestral sequence and evolution of sequence between 2.25 and The random divergence between the two homologous sequence compared with 1.9.