GPs100 μ g/ml can also fight methylene blue (Mb) induced vascular ring diastolic function injury.Vascular endothelial release of prostacyclin (PGI2) and endothelial derived relaxing factor (EDRF) and the regulation of vascular tone and strengthen its anti-damage ability, OFR induced vasodilatation capacity decreases with the decrease of endothelial EDRF release, GPs can antagonize the inhibition of EDRF by Mb induced vasodilation in lower EDRF activity, GPs may protect.The effect of GPs could be inhibited by INDO, showed that the GPs effect may be through the promotion of tissue release PGI2 and anti lipid peroxidation, reduces human neutrophil intracellular superoxide anion and hydrogen peroxide content; on human monocytes and macrophages in rats, GPs can decrease yeast polysaccharide triggered chemiluminescence oxidative burst; for Fe2+ cysteine -NADPH, ascorbic acid or hydrogen peroxide in liver microsomes and vascular endothelial cells produce LPO increased, GPs can inhibit this effect, due to oxidative damage and reduced liver microsomes and shallow bulk membrane fluidity, GPs can be reversed, increased vascular endothelial cell mitochondria enzyme activity.Reduction of these intracellular lactate dehydrogenase leakage, suggesting that GPs may protect the membrane from oxidative damage, GPs these broad antioxidant effect on various diseases such as arterial congee Xiang hardening, the prevention and treatment of liver disease and inflammation may have pricing.It is pointed out that lipid peroxidation may cause higher content of biological membrane lipid composition changes, and that the DNA, RNA structure damage, caused by protein cross-linking, resulting in cell senescence, Gynostemma pentaphyllum significantly reduced LPO role worthy of attention.Gynostemma pentaphyllum can inhibit fat cells produce free fatty acids and synthesis of neutral fat.Using a rat epididymal adipose tissue preparation of fatty cells were cultured in the medium with ACTH, or epinephrine to the decomposition of fat cells and produce free fatty acids, such as adding GPs reduction of free fatty acid production reached about 28%.In fat cells and tracer compounds 14C- glucose at 37 ℃ fostered 30 minutes, the determination of fat cell pulses per minute (CPM) as the glucose into the cells for synthesis of neutral point to defend the index, medium after adding GPs, per gram of fat cells measured CPM number is only about 50% without GPs group.
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